3,4-difluorobenzylzinc bromide solution
bromo-[(3,4-difluorophenyl)methyl]zinc
CAS: 307496-34-0
Molecular Formula: C7H5BrF2Zn
3,4-difluorobenzylzinc bromide solution - Names and Identifiers
| Name | bromo-[(3,4-difluorophenyl)methyl]zinc |
| Synonyms | Bromo(3,4-difluorobenzyl)zinc 3,4-DIFLUOROBENZYLZINC BROMIDE bromo-[(3,4-difluorophenyl)methyl]zinc 3,4-difluorobenzylzinc bromide solution 3,4-DIFLUOROBENZYLZINC BROMIDE, 0.5M SOL 3,4-Difluorobenzylzinc bromide solution 0.5 in THF 3,4-Difluorobenzylzinc bromide 0.5M solution in THF 3,4-Difluorobenzylzinc broMide, 0.5 M solution in THF, SpcSeal 3,4-Difluorobenzylzinc bromide, Packaged under Argon in resealable ChemSeal? bottles |
| CAS | 307496-34-0 |
| InChI | InChI=1/C7H5F2.BrH.Zn/c1-5-2-3-6(8)7(9)4-5;;/h2-4H,1H2;1H;/q;;+1/p-1/rC7H5BrF2Zn/c8-11-4-5-1-2-6(9)7(10)3-5/h1-3H,4H2 |
3,4-difluorobenzylzinc bromide solution - Physico-chemical Properties
| Molecular Formula | C7H5BrF2Zn |
| Molar Mass | 272.41 |
| Density | 0.98g/mLat 25°C |
| Flash Point | 1°F |
| Water Solubility | Reacts with water. |
| Exposure Limit | ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)OSHA: TWA 200 ppm(590 mg/m3)NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) |
| Storage Condition | 2-8°C |
| Sensitive | Air Sensitive |
3,4-difluorobenzylzinc bromide solution - Risk and Safety
| Risk Codes | R14 - Reacts violently with water R19 - May form explosive peroxides R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R40 - Limited evidence of a carcinogenic effect R36/37 - Irritating to eyes and respiratory system. R11 - Highly Flammable |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S33 - Take precautionary measures against static discharges. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2056 3/PG 2 |
| WGK Germany | 1 |
| Hazard Note | Flammable |
| Hazard Class | 4.3 |
3,4-difluorobenzylzinc bromide solution - Introduction
bromo-[(3,4-difluorophenyl)methyl] Inc is an organic compound. Its molecular formula is C8H5BrF2Zn, and its relative molecular mass is 286.3g/mol.
Nature:
bromo-[(3,4-difluorophenyl)methyl]zinc is a colorless to light yellow solid. It is readily soluble in inert organic solvents (such as dimethylformamide, chlorinated methane, etc.), but insoluble in water. It is more sensitive to air and moisture, easy to decompose in the air.
Use:
bromo-[(3,4-difluorophenyl)methyl]zinc is an important reagent in organic synthesis. It is commonly used as a metal organic reagent to catalyze coupling reactions. It can be reacted with an organic halide to form the corresponding Allyl, propargyl or alkyl compound. Common reactions include Suzuki reaction, Stille reaction, etc. It is widely used in the fields of medicine, pesticide and material science.
Method:
The preparation of bromo-[(3,4-difluorophenyl)methyl]zinc is generally obtained by the reaction of zinc bromide and 3,4-difluorobenzyl Cadmium bromide. First, zinc bromide is reacted with Cadmium bromide in an inert solvent to form a mixture of zinc bromide and Cadmium bromide, and then the product is reacted with 3,4-difluorobenzyl bromide, bromo-[(3,4-difluorophenyl)methyl]zinc was obtained.
Safety Information:
bromo-[(3,4-difluorophenyl)methyl]zinc needs to be operated in a well-ventilated environment, avoiding contact with skin, eyes and inhalation. Appropriate protective equipment, such as protective gloves, safety glasses and face shields, should be worn. During use and storage, safety operating procedures should be strictly followed and contact with oxidants should be avoided to prevent fire or explosion. In case of accidental spills or poisoning, appropriate emergency treatment should be carried out in a timely manner and medical assistance should be sought.
Nature:
bromo-[(3,4-difluorophenyl)methyl]zinc is a colorless to light yellow solid. It is readily soluble in inert organic solvents (such as dimethylformamide, chlorinated methane, etc.), but insoluble in water. It is more sensitive to air and moisture, easy to decompose in the air.
Use:
bromo-[(3,4-difluorophenyl)methyl]zinc is an important reagent in organic synthesis. It is commonly used as a metal organic reagent to catalyze coupling reactions. It can be reacted with an organic halide to form the corresponding Allyl, propargyl or alkyl compound. Common reactions include Suzuki reaction, Stille reaction, etc. It is widely used in the fields of medicine, pesticide and material science.
Method:
The preparation of bromo-[(3,4-difluorophenyl)methyl]zinc is generally obtained by the reaction of zinc bromide and 3,4-difluorobenzyl Cadmium bromide. First, zinc bromide is reacted with Cadmium bromide in an inert solvent to form a mixture of zinc bromide and Cadmium bromide, and then the product is reacted with 3,4-difluorobenzyl bromide, bromo-[(3,4-difluorophenyl)methyl]zinc was obtained.
Safety Information:
bromo-[(3,4-difluorophenyl)methyl]zinc needs to be operated in a well-ventilated environment, avoiding contact with skin, eyes and inhalation. Appropriate protective equipment, such as protective gloves, safety glasses and face shields, should be worn. During use and storage, safety operating procedures should be strictly followed and contact with oxidants should be avoided to prevent fire or explosion. In case of accidental spills or poisoning, appropriate emergency treatment should be carried out in a timely manner and medical assistance should be sought.
Last Update：2024-04-09 02:00:45
